Publications
J.W. Benning*, J. Carlson*, Ruth Shaw, A. Harpak+. Clark (2023) and the Persistence of Hereditarian Fallacies. bioRxiv 2023.
K. Hou. Z. Xu, Y. Ding, A. Harpak, B. Pasaniuc. Calibrated prediction intervals for polygenic scores across diverse contexts. medRxiv 2023.
E. Weine, S.P. Smith, R.K. Knowlton, A. Harpak+. Tradeoffs in Modeling context dependency in Complex Trait Genetics. bioRxiv 2023.
S.P. Smith*. G. Darnell*, D. Udwin, A. Harpak, S. Ramachandran, L. Crawford,. Accounting for statistical non-additive interactions enables the recovery of missing heritability from GWAS summary statistics. bioRxiv 2023.
C. Zhu, M.J. Ming, J.M. Cole, M.D. Edge, M. Kirkpatrick, A. Harpak+. Amplification is the primary mode of gene-by-sex interaction in complex human traits. Cell Genomics 2023. (Press Release)
M. Le, O. Smith, A. Akbari, A. Harpak+, D. Reich+,,, V.M. Narasimhan+. 1,000 ancient genomes uncover 10,000 years of natural selection in Europe. bioRxiv 2022.
A. Harpak+ & M.D. Edge. GWAS deems parents guilty by association. Proceedings of the National Academy of Sciences (PNAS) 2021.
S. Mohammadi*, L. Yang*, A. Harpak*, M. Rodríguez-Ordoñez, S.H. Alvarez, J. Storz, S. Dobler, A., Crawford, P. Andolfatto. Selection maintains co-adapted amino acid substitutions in toxin resistant toad-eating frogs. Current Biology 2021.
A. Harpak+ & M. Przeworski+. The Evolution of Group Differences in Changing Environments. PLoS Biology 2021
Q. Yu, M. Gralka, M. Duvernoy, M. Sousa, A. Harpak, O. Hallatschek. Mutability of demographic noise in microbial range expansions. ISMEJ 2021; (featured in Nature Microbiology Community)
A. Harpak+, N.R. Garud, N.A. Rosenberg, D.A. Petrov, Matthew Combs, P.S. Pennings, J. Munshi-South+. Genetic Adaptation in New York City Rats. Genome Biology and Evolution 2020; (featured in Nature, The Guardian, The Independent, New York Post, Newsweek, The Sun and more)
H. Mostafavi*,+, A. Harpak*,+, I. Agarwal, D. Conley, J.K. Pritchard, M. Przeworski+. Variable Prediction Accuracy of Polygenic Scores Within an Ancestry Group. eLife 2020; featured in a VICE article and an eLife Digest)
J.J. Berg*, A. Harpak*, N. Sinnott-Armstrong*, A.M. Jørgensen, H. Mostafavi, Y. Field, E.A. Boyle, X. Zhang, F. Racimo, J.K. Pritchard, G. Coop. Reduced signal for polygenic adaptation of height in UK Biobank. eLife, 2019 (cited over 150 times in one year post publication; featured in an eLife editorial and in Quanta magazine)
E. Glassberg, Z. Gao, A. Harpak, X. Lan, J.K. Pritchard. Measurement of selective constraint on human gene expression. Genetics, 2019 (Chosen as GSA Genetics Spotlight publication for 2019)
V. Garcia, E.C. Glassberg, A. Harpak, M.W. Feldman. Finite-sites multiple mutations interference gives rise to wavelet-like oscillations of multilocus linkage disequilibrium. Journal of the Royal Society Interface, 2018
A. Harpak+,*, X. Lan*, Z. Gao, J.K. Pritchard+. Frequent nonallelic gene conversion on the human lineage and its effect on the divergence of gene duplicates. Proceedings of the National Academy of Sciences (PNAS), 2017
R. Sun, Z. Hu, A. Sottoriva, T.A. Graham, A. Harpak, Z. Ma, J.M. Fischer, D. Shibata, C. Curtis. Genetic Diversity in Multi-Region Sequencing Data Reflects the Mode and Tempo of Tumor Evolution. Nature Genetics, 2017
A. Harpak+,*, A. Bhaskar*, J.K. Pritchard. Effects of mutation rate variation on the distribution of allele frequencies in humans. PLoS Genetics, 2016 (award for 1/10 best abstracts by the American Society of Human Genetics (ASHG); F1000Prime recommended paper)
A. Raj, S. Wang, H. Shim, A. Harpak, Y.I. Li, B. Engelmann, M. Stephens, Y. Gilad, J. K. Pritchard. Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling. eLife, 2016
A. Harpak+ and G. Sella+. Neutral null models for diversity in serial transfer evolution experiments. Evolution, 2014